Scanner or graphic tablet

[Kasander]

I often wonder if they scanned in the Mechinarium artwork, and if they touched it up at all later.

Yeah, those guys from Amanita know how to rock with their pencils & tablets... 

Here you are:
http://www.gamasutra.com/blogs/JimMcGinley/20091202/3694/MIGS_Day_1_1015am_Machinarium_makes_claymation_look_efficient.php

According to this, the artist drew with his left (in his case, secondary) hand

[EchosofNezhyt]

Getting used to a tablet takes a few mins to a few days.

Or much more. It took me months before I was fairly comfortable with my tablet, and I still (after years of - admittedly fairly occasional - use) can't e.g. draw a straight line between two points in freehand.

Ah. I'd I figured it was a easy switch for most people I prefer it over paper by huge margin.

I drew alot with a mouse and I pickup on artistic stuff really maybe that helped /shrug.

[Vroni]

I draw all my backgrounds and the sprites with the ASEprite editor by using the mouse. I've got a tablet, but I don't like it.
My BGs look kind of weird cause I'm a freestyler: 
First I start with a sketch (by using the editor)
Then I search for the right colors in the RPG palette and start to draw

It is still not finish as you can see here:

320x240 true color


... I use the blur tool for the edges and the jumble tool for the finish... With the ASE you can also scale to index colors with/without dithering